FLT3 mutations are the most frequently identified genetic alterations in acute myeloid leukemia (AML) and are associated with poor clinical outcome, Bumpers relapse and chemotherapeutic resistance.Elucidating the molecular mechanisms underlying FLT3-dependent pathogenesis and drug resistance is a crucial goal of biomedical research.Given the comple
The advent of deep-sea exploration using video cameras has uncovered extensive sponge aggregations in virtually all oceans.Yet, a distinct type is herein reported from the Mediterranean: a monospecific Styling Gel reef-like formation built by the lithistid demosponge Leiodermatium pfeifferae.Erect, plate-like individuals (up to 80 cm) form bulky cl
Cadherin 23 (CDH23), a component of tip links in hair cells of vertebrate animals, is essential to mechanotransduction by hair cells in the inner ear.A homolog of CDH23 occurs in hair bundles of sea anemones.Anemone hair bundles are located on the tentacles where they detect the swimming movements of nearby prey.The anemone CDH23 is predicted to be
Since the recognition of asymptomatic bacteriuria (ABU), several studies have questioned its significance.It is Dispensers a very common condition, observed in many healthy individuals.Current guidelines mandate that ABU should not be treated in all cases, as it does not seem to improve the outcome.Conditional restrictions for treatment of ABU can